![tert-Butyl 6-chloro-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate structure](https://static.chemtradehub.com/structs/101/1011482-37-3-88a5.webp "tert-Butyl 6-chloro-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate structure")
tert-Butyl 6-chloro-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate
CAS Number:
1011482-37-3
Molecular Formula:
C18H22ClNO4
A novel calix[4]arene-based bifunctional squaramide organocatalyst for enantioselective Michael addition of acetylacetone to nitroolefins
Literature Information
Publication Date
2016-04-12
DOI
10.1039/C6QO00135A
Impact Factor
5.281
Authors
Ummu Vural, Mustafa Durmaz, Abdulkadir Sirit
View Original
Abstract
A new chiral calix[4]arene-based organocatalyst 3 bearing bis-squaramide moieties was designed and synthesized from p-tert-butylcalix[4]arene. This bifunctional squaramide organocatalyst was used in the enantioselective conjugate addition of acetylacetone to β-nitrostyrenes. The corresponding adducts were obtained in good to excellent yields with high enantioselectivities (up to 94% ee).
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
N1,N1-Bis(4-aminophenyl)benzene-1,4-diamine trihydrochloride
CAS Number:
114254-48-7
Molecular Formula:
C18H21Cl3N4
(2S)-2-(Fluoromethyl)piperidine hydrochloride (1:1)
CAS Number:
886216-73-5
Molecular Formula:
C6H13ClFN
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