Rapid and sensitive monitoring of biocatalytic reactions using ion mobility mass spectrometry
Literature Information
Publication Date
2016-03-15
DOI
10.1039/C6AN00617E
Impact Factor
4.616
Authors
Cunyu Yan, Jason W. Schmidberger, Fabio Parmeggiani, Shaneela A. Hussain, Nicholas J. Turner, Sabine L. Flitsch, Perdita Barran
View Original
Abstract
The combination of stable isotope labelling with direct infusion ion mobility mass spectrometry (IM-MS) enabled qualitative and quantitative monitoring of biocatalytic reactions with reduced analysis times, enhanced sensitivity and μL-level assay volumes. The new approach was demonstrated by applying to both lipase and monooxygenase enzymes, including multi-substrate screening.
Recommended Journals
Related Literature
A general approach to stereospecific Pd-catalyzed cross-coupling reactions of benzylic stereocenters
2023-11-24
Edge Article
DOI: 10.1039/D3SC04519F
Strain induced reactivity of cyclic iminoboranes: the (2 + 2) cycloaddition of a 1H-1,3,2-diazaborepine with ethene
Divanshu Gupta, Ralf Einholz, Holger F. Bettinger
2023-12-12
Edge Article
DOI: 10.1039/D3SC04901A
Supramolecular “baking powder”: a hexameric halogen-bonded phosphonium salt cage encapsulates and functionalises small-molecule carbonyl compounds
Hatem M. Titi, Yong Teoh
2023-11-28
Edge Article
DOI: 10.1039/D2SC04615F
Rapid, iterative syntheses of unsymmetrical di- and triarylboranes from crystalline aryldifluoroboranes
Douglas Turnbull, Marc-André Légaré
2023-11-17
Edge Article
DOI: 10.1039/D3SC05071H
Interface regulation of the Zn anode by using a low concentration electrolyte additive for aqueous Zn batteries
Kuo Wang, Qianrui Li, Guoli Zhang, Shuo Li, Tong Qiu
2023-12-06
Edge Article
DOI: 10.1039/D3SC05098J
EnzymeMap: curation, validation and data-driven prediction of enzymatic reactions
Daniel Probst, William H. Green, Georg K. H. Madsen
2023-11-22
Edge Article
DOI: 10.1039/D3SC02048G
Metal selectivity and translocation mechanism characterization in proteoliposomes of the transmembrane NiCoT transporter NixA from Helicobacter pylori
Jayoh A. Hernandez, Paul S. Micus, Sean Alec Lois Sunga, Luca Mazzei, Stefano Ciurli, Gabriele Meloni
2023-11-29
Edge Article
DOI: 10.1039/D3SC05135H
Photocatalytic, modular difunctionalization of alkenes enabled by ligand-to-metal charge transfer and radical ligand transfer
Kang-Jie Bian, David Nemoto, Jr, Xiao-Wei Chen, Shih-Chieh Kao, James Hooson, Julian G. West
2023-11-24
Edge Article
DOI: 10.1039/D3SC05231A
Photoredox-catalyzed stereo- and regioselective vicinal fluorosulfonyl-borylation of unsaturated hydrocarbons
Heyin Li, Mengjun Huang, Zhenlei Zou, Zhen Wang, Yifan Li, Chao Sun, Wangzhe Chen, Yi Pan, Weigang Zhang, Yi Wang
2023-11-13
Edge Article
DOI: 10.1039/D3SC03101B
A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase
Pedro Zuazua-Villar, Oliwia Koczy, Andrew J. Counsell, Stephen J. Walsh, Naomi S. Robertson, David R. Spring, Jessica A. Downs, Marko Hyvönen
2023-11-21
Edge Article
DOI: 10.1039/D3SC03331G
You might also like
Compound Q&A
What precautions should be taken when handling 4-(2-Furylmethyl)thiomorpholine 1,1-dioxide (CAS: 79206-94-3)?
When handling 4-(2-Furylmethyl)thiomorpholine 1,1-dioxide (CAS: 79206-94-3), it ...
79206-94-34-(2-Furylmethyl)thi...
Compound Q&A
What precautions should be taken when handling 4-Chloro-N-[2-(4-morpholinyl)ethyl]benzamide (CAS: 71320-77-9)?
When handling 4-Chloro-N-[2-(4-morpholinyl)ethyl]benzamide (CAS: 71320-77-9), it...
71320-77-94-Chloro-N-[2-(4-mor...
Compound Q&A
How should waste containing 2-[2-(2-Methoxyethoxy)ethoxy]ethyl 4-methylbenzenesulfonate (CAS: 62921-74-8) be handled?
Waste containing this compound (CAS: 62921-74-8) should be handled according to ...
62921-74-82-[2-(2-Methoxyethox...
Compound Q&A
How should waste containing (S)-Methyl 2-amino-3-cyclohexylpropanoate be handled?
Waste containing (S)-Methyl 2-amino-3-cyclohexylpropanoate should be collected i...
40056-18-6(S)-Methyl 2-amino-3...
Compound Q&A
How is 5-({4-[(2S,4R)-4-Hydroxy-2-methyltetrahydro-2H-pyran-4-yl]-2-thienyl}sulfanyl)-1-methyl-1,3-dihydro-2H-indol-2-one (CAS: 166882-70-8) typically synthesized?
This compound can be synthesized using a multi-step process involving the conjug...
166882-70-85-({4-[(2S,4R)-4-Hyd...
Compound Q&A
Are there alternatives to (2E)-3-(3,4-Dichlorophenyl)acrylic acid (CAS: 7312-27-8) in synthesis?
There are several alternatives to (2E)-3-(3,4-Dichlorophenyl)acrylic acid in syn...
7312-27-8(2E)-3-(3,4-Dichloro...
Compound Q&A
How should Ethyl 6-(2-nitrophenyl)imidazo[2,1-b][1,3]thiazole-3-carboxylate (CAS: 925437-84-9) be stored?
Ethyl 6-(2-nitrophenyl)imidazo[2,1-b][1,3]thiazole-3-carboxylate (CAS: 925437-84...
925437-84-9Ethyl 6-(2-nitrophen...
Compound Q&A
How should waste containing 2-(1,3-Thiazol-2-yl)ethanamine (CAS: 18453-07-1) be handled?
Waste containing 2-(1,3-Thiazol-2-yl)ethanamine (CAS: 18453-07-1) should be coll...
18453-07-12-(1,3-Thiazol-2-yl)...
Compound Q&A
How is Methyl 5-iodo-2-methylbenzoate (CAS: 103440-54-6) typically synthesized?
Methyl 5-iodo-2-methylbenzoate can be synthesized through the iodination of meth...
103440-54-6Methyl 5-iodo-2-meth...
Compound Q&A
How is 5-Chloro[1,2,4]triazolo[1,5-a]pyridine (CAS: 1427399-34-5) typically synthesized?
5-Chloro[1,2,4]triazolo[1,5-a]pyridine is commonly synthesized via the condensat...
1427399-34-55-Chloro[1,2,4]triaz...
Source Journal
Analyst
CiteScore:
7.8
Self-citation Rate:
5.6%
Articles per Year:
653
Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
(3-Oxo-1,2,3,4-tetrahydro-2-quinoxalinyl)acetic acid
CAS Number:
136584-14-0
Molecular Formula:
C10H10N2O3
Recommended Suppliers
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.