A high-resolution method to assess cell multinucleation with cytoplasm-localized fluorescent probes
Literature Information
Publication Date
2016-05-19
DOI
10.1039/C6AN00613B
Impact Factor
4.616
Authors
Qinghua Cui, Hui Meng, Fangfang Lai, Shufang Wang, Xiang Zhang, Xiaoguang Chen, Dali Yin
View Original
Abstract
Cell multinucleation is closely related to chromosomal instability. We report a simple, convenient method to assess cell multinucleation with cytoplasm-localized fluorescent probes (CLFP) which is superior to conventional nuclear staining methods. The CLFP method provides high-resolution images that enable the accurate calculation of the number of nuclear fragments.
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