Access to bicyclic hydroxamate macrocycles via intramolecular aza-(4 + 3) cyloaddition reactions of aza-oxyallylic cation intermediates
Literature Information
Publication Date
2015-12-28
DOI
10.1039/C5QO00315F
Impact Factor
5.281
Authors
A. Acharya, J. A. Eickhoff, K. Chen, V. J. Catalano, C. S. Jeffrey
View Original
Abstract
The intramolecular aza-(4 + 3) cycloaddition reactions of in situ generated aza-oxyallylic cations and furans have been reported for the construction of medium sized hydroxamate macrocycles. This method provides direct access to 12–18 membered bicyclic macrocycles. The highly functionalized macrocycles have been transformed easily in to a wide range of highly functionalized heterocyclic scaffolds including lactones and lactams that could serve the synthesis of complex macrocyclic natural products and pharmaceuticals.
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Source Journal
Organic Chemistry Frontiers
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