A water-soluble polymer for selective colorimetric sensing of cysteine and homocysteine with temperature-tunable sensitivity

Literature Information

Publication Date 2014-05-19
DOI 10.1039/C4PY00476K
Impact Factor 5.582
Authors

A. Balamurugan, Hyung-il Lee


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Abstract

A water-soluble polymeric probe for selective sensing of cysteine and homocysteine by colorimetric titration was designed and synthesized. Most interestingly, temperature-tunable sensitivity of cysteine detection was achieved. The polymer selectivity toward various amino acids was investigated, and the highest selectivity (25–30-fold higher) was achieved for cysteine and homocysteine compared to other amino acids. The temperature-dependent cysteine sensing studies were performed to demonstrate temperature-tunable sensitivity towards cysteine. The sensing ability decreased with increasing temperature from 25 to 55 °C due to hydrophobic aldehyde moieties being hidden in the folded chains of the polymer.

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Polymer Chemistry

Polymer Chemistry
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