Palladium-catalyzed Br/D exchange of arenes: selective deuterium incorporation with versatile functional group tolerance and high efficiency
Literature Information
Publication Date
2015-07-13
DOI
10.1039/C5QO00181A
Impact Factor
5.281
Authors
Hong-Hai Zhang, Peter V. Bonnesen, Kunlun Hong
View Original
Abstract
A facile method for introducing one or more deuterium atoms onto an aromatic nucleus via Br/D exchange with high functional group tolerance and high incorporation efficiency is disclosed. Deuterium-labeled aryl chlorides and aryl borates which could be used as substrates in cross-coupling reactions to construct more complicated deuterium-labeled compounds can also be synthesized by this method.
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Organic Chemistry Frontiers
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