Supported lipid bilayer repair mediated by AH peptide
Literature Information
Anders Gunnarsson, Fredrik Höök
The adsorption and fusion of small unilamellar lipid vesicles on silica-based substrates such as glass is a common method used to fabricate supported lipid bilayers. Successful bilayer formation depends on a number of experimental conditions as well as on the quality of the vesicle preparation. Inevitably, a small fraction of unruptured vesicles always remains in a supported bilayer, and this kind of defect can have devastating influences on the morphological and electrical properties of the supported bilayer when used as a biosensing platform. In this paper, a simple method is reported to improve the completeness of supported bilayers by adding a vesicle rupturing peptide as a final step in the fabrication process. Peptide treatment reduces the fraction of unruptured vesicles to less than 1%, as determined by epifluorescence microscopy and quartz crystal microbalance-dissipation experiments. This step can easily be incorporated into existing procedures for preparing high-quality supported lipid bilayers.
Recommended Journals

Journal of the Indian Institute of Science

Bioorganic & Medicinal Chemistry

Medicinal Chemistry Research

Journal of Chemical Sciences

Chinese Journal of Chemistry

Topics in Catalysis

Polycyclic Aromatic Compounds

Bioorganic & Medicinal Chemistry Letters

Journal of Asian Natural Products Research

Heteroatom Chemistry
Related Literature
Challenges and opportunities of pharmaceutical cocrystals: a focused review on non-steroidal anti-inflammatory drugs
Utsav Garg, Yasser Azim
DOI: 10.1039/D0MD00400F
Introducing the metacore concept for multi-target ligand design
Dagmar Stumpfe, Alexander Hoch, Jürgen Bajorath
DOI: 10.1039/D1MD00056J
Irreversible inhibition of BoNT/A protease: proximity-driven reactivity contingent upon a bifunctional approach
Lewis D. Turner, Lucy Lin, Sabine Pellett, Takashi Sugane, Eric A. Johnson, Kim D. Janda
DOI: 10.1039/D1MD00089F
Synthesis and structure–activity relationships of 3,4,5-trisubstituted-1,2,4-triazoles: high affinity and selective somatostatin receptor-4 agonists for Alzheimer's disease treatment
William L. Neumann, Karin E. Sandoval, Shirin Mobayen, Mahsa Minaeian, Stephen G. Kukielski, Khush N. Srabony, Rafael Frare, Olivia Slater, Susan A. Farr, Michael L. Niehoff, Audrey Hospital, Maria Kontoyianni, A. Michael Crider, Ken A. Witt
DOI: 10.1039/D1MD00044F
Novel fluorinated ring-fused chlorins as promising PDT agents against melanoma and esophagus cancer
Nelson A. M. Pereira, Bruno F. O. Nascimento, João Pina, Gonçalo Brites, J. Sérgio Seixas de Melo, Marta Pineiro, Teresa M. V. D. Pinho e Melo
DOI: 10.1039/D0MD00433B
Amino alcohol acrylonitriles as broad spectrum and tumour selective cytotoxic agents
Jennifer R. Baker, Cecilia C. Russell, Jayne Gilbert, Adam McCluskey, Jennette A. Sakoff
DOI: 10.1039/D1MD00021G
Identification of P218 as a potent inhibitor of Mycobacterium ulcerans DHFR
Rachael Zigweid, Bart L. Staker
DOI: 10.1039/D0MD00303D
You might also like
How should waste containing 6-Chloro-5-(2'-hydroxy-3'-methoxy-4-biphenylyl)-3-(3-methoxyphenyl)-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione (CAS: 1346607-05-3) be handled?
Waste containing 6-Chloro-5-(2'-hydroxy-3'-methoxy-4-biphenylyl)-3-(3-methoxyphe...
What are the main uses of (3alpha,5alpha)-3-Hydroxypregnane-11,20-dione (CAS: 23930-19-0)?
(3alpha,5alpha)-3-Hydroxypregnane-11,20-dione is primarily used in the pharmaceu...
What is the market or research trend for 4-Amino-6-chloro-2-pyridinecarboxylic acid (CAS: 546141-56-4)?
The market for 4-Amino-6-chloro-2-pyridinecarboxylic acid (CAS: 546141-56-4) is ...
Are there alternatives to (2-Benzoylethyl)trimethylammonium chloride (CAS: 24472-88-6) in synthesis?
Alternatives to (2-Benzoylethyl)trimethylammonium chloride (CAS: 24472-88-6) in ...
Is N-[4-Nitro-3-(trifluoromethyl)phenyl]acetamide (CAS: 393-12-4) safe?
N-[4-Nitro-3-(trifluoromethyl)phenyl]acetamide (CAS: 393-12-4) is generally safe...
Are there alternatives to [(4R,5R,6S)-5-hydroxy-10-imino-3,7-dioxa-1,9-diazatricyclo[6.4.0.02,6]dodeca-8,11-dien-4-yl]methyl dihydrogen phosphate (CAS: 39679-56-6) in synthesis?
Alternative reagents such as other phosphates or similar functional groups can b...
Are there alternatives to N,N'-Bis(3-aminopropyl)-1,3-propanediamine (CAS: 4605-14-5) in synthesis?
There are alternatives to N,N'-Bis(3-aminopropyl)-1,3-propanediamine (CAS: 4605-...
What precautions should be taken when handling Aluminium trihexadecanoate (CAS: 555-35-1)?
When handling Aluminium trihexadecanoate, it is important to use appropriate per...
What is (1,1-Dioxido-3-oxo-1,2-benzothiazol-2(3H)-yl)acetic acid (CAS: 52188-11-1)?
(1,1-Dioxido-3-oxo-1,2-benzothiazol-2(3H)-yl)acetic acid is a chemical compound ...
Are there alternatives to 5,5-dimethyloxolan-2-one (CAS: 3123-97-5) in synthesis?
Several alternatives to 5,5-dimethyloxolan-2-one (CAS: 3123-97-5) can be used in...
Source Journal
Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.


![Benzo[b]naphtho[2,1-d]thiophene structure Benzo[b]naphtho[2,1-d]thiophene structure](https://static.chemtradehub.com/structs/239/239-35-0-ff90.webp)

![(3-{[4-(Aminomethyl)-6-(trifluoromethyl)-2-pyridinyl]oxy}phenyl)[(3R,4R)-3-fluoro-4-hydroxy-1-pyrrolidinyl]methanone structure (3-{[4-(Aminomethyl)-6-(trifluoromethyl)-2-pyridinyl]oxy}phenyl)[(3R,4R)-3-fluoro-4-hydroxy-1-pyrrolidinyl]methanone structure](https://static.chemtradehub.com/structs/200/2007885-39-2-affc.webp)