Hyperpolarized NMR of plant and cancer cell extracts at natural abundance

Literature Information

Publication Date 2015-07-20
DOI 10.1039/C5AN01203A
Impact Factor 4.616
Authors

Jean-Nicolas Dumez, Jonas Milani, Basile Vuichoud, Aurélien Bornet, Julie Lalande-Martin, Lucio Frydman, Sami Jannin


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Abstract

Natural abundance 13C NMR spectra of biological extracts are recorded in a single scan provided that the samples are hyperpolarized by dissolution dynamic nuclear polarization combined with cross polarization. Heteronuclear 2D correlation spectra of hyperpolarized breast cancer cell extracts can also be obtained in a single scan. Hyperpolarized NMR of extracts opens many perspectives for metabolomics.

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