Synthesis of 3-cyanomethylated coumarins by a visible-light-mediated direct cyanomethylation of aryl alkynoates
Literature Information
Wei Zhang, Chen Yang, Yu-Liang Pan, Xin Li, Jin-Pei Cheng
A visible-light-promoted, mild, and direct cyanomethylation of aryl alkynoates has been developed. This method provides a new strategy toward the synthesis of 3-cyanomethylated coumarins via a domino radical addition/5-exo cyclization/ester migration cascade reaction in moderate to good yields at room temperature. Converting the resulting products into various molecules exhibited the synthetic utility of the present methodology.
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Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.












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