Fluorescent PEGylation agent by a thiolactone-based one-pot reaction: a new strategy for theranostic combinations
Literature Information
Publication Date
2014-08-12
DOI
10.1039/C4PY00995A
Impact Factor
5.582
Authors
Yuan Zhao, Bin Yang, Yaling Zhang, Shiqi Wang, Changkui Fu, Yen Wei, Lei Tao
View Original
Abstract
Theranostic combinations usually contain an imaging, a therapeutic and a cloaking component to simultaneously fulfil diagnostic and therapeutic functions. Using upgraded PEGylation technology, a straightforward one-pot strategy based on thiolactone ring-opening has been developed to facilely synthesize a multifunctional PEGylation agent, fluorescent protein-reactive poly(ethylene glycol) (PEG), which can subsequently react with a model therapeutic protein to form a fluorescent PEGylated protein as a model of sophisticated theranostic combinations.
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Source Journal
Polymer Chemistry
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