Michaelis–Menten kinetics under non-isothermal conditions

Literature Information

Publication Date 2014-11-18
DOI 10.1039/C4CP04334K
Impact Factor 3.676
Authors

Anders Lervik, Hong Qian


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Abstract

We extend the celebrated Michaelis–Menten kinetics description of an enzymatic reaction taking into consideration the presence of a thermal driving force. A coupling of chemical and thermal driving forces is expected from the principle of non-equilibrium thermodynamics, and specifically we obtain an additional term to the classical Michaelis–Menten kinetic equation, which describes the coupling in terms of a single parameter. A companion equation for the heat flux is also derived, which actually can exist even in the absence of a temperature difference. Being thermodynamic in nature, this result is general and independent of the detailed mechanism of the coupling. Conditions for the experimental verification of the new equation are discussed.

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DOI: 10.1039/C8CP91816C

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Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
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