Benzyl 3-(aminomethyl)piperidine-1-carboxylate hydrochloride
CAS Number:
1186663-23-9
Molecular Formula:
C14H21ClN2O2
Photochemical thiol–yne functionalization of polypeptide scaffolds
Literature Information
Publication Date
2013-05-01
DOI
10.1039/C3PY00428G
Impact Factor
5.582
Authors
Kai-Steffen Krannig, Jin Huang, Andreas Heise, Helmut Schlaad
View Original
Abstract
Copolypeptides with propargyl side chains were functionalized with different thiols (1-thio-β-D-glucose tetraacetate, 7-mercapto-4-methylcoumarin, and methyl-3-mercaptopropionate) by initiator/catalyst-free thiol–yne photochemistry. No more than 1.5 instead of ideally 2 equivalents of thiol could be added to the propargyl units even when the thiol was used in excess, attributable to steric constraints (close proximity of the reaction site to the copolypeptide backbone) or conjugation (extended aromatic system). Nevertheless, this procedure enables a facile and modular synthesis of highly functionalized homo- and hetero-functional copolypeptides.
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Source Journal
Polymer Chemistry
CiteScore:
8.6
Self-citation Rate:
7.3%
Articles per Year:
457
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
Recommended Compounds
(11alpha,13E)-11-Hydroxy-9,15-dioxoprost-13-en-1-oic acid
CAS Number:
22973-19-9
Molecular Formula:
C20H32O5
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