Enzymatic halogenation of the phenolic monoterpenes thymol and carvacrol with chloroperoxidase

Literature Information

Publication Date 2013-11-28
DOI 10.1039/C3GC42269K
Impact Factor 10.182
Authors

Laura Getrey, Thomas Krieg, Frank Hollmann, Jens Schrader, Dirk Holtmann


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Abstract

The conversion of the phenolic monoterpenes thymol and carvacrol into antimicrobials by (electro)-chemoenzymatic halogenation was investigated using a chloroperoxidase (CPO) catalyzed process. The CPO catalysed process enables for the first time the biotechnological production of chlorothymol, chlorocarvacrol and bromothymol as well as a dichlorothymol with high conversion rates, total turnover numbers and space time yields of up to 90%, 164 000 and 4.6 mM h−1, respectively.

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