Nanoparticle catalyzed reaction (NPCR): ZnO-NP catalyzed Ugi-reaction in aqueous medium‡

Literature Information

Publication Date 2013-07-09
DOI 10.1039/C3GC41101J
Impact Factor 10.182
Authors

Atul Kumar, Deepti Saxena, Maneesh Kumar Gupta


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Abstract

The first ZnO-NP catalyzed Ugi type three-component (AB2C) reaction has been developed for the synthesis of 2-arylamino-2-phenylacetimidamide from an aldehyde, amine and isocyanide in aqueous media. This nanoparticle catalysed reaction (NPCR) is high yielding and has good atom economy as well as atom efficiency. The synthesized phenylacetimidamide yielded 2-amino-2-phenylacetamide on hydrolysis with I2–SDS–water, whereas alkaline hydrolysis afforded the N-substituted α-amino acid.

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