Multistep synthesis of amides from alcohols and amines in continuous flow microreactor systems using oxygen and ureahydrogen peroxide as oxidants

Literature Information

Publication Date 2013-04-02
DOI 10.1039/C3GC40407B
Impact Factor 10.182
Authors

Xiaoying Liu, Klavs F. Jensen


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Abstract

By integrating a heterogeneous oxidation step, gas–liquid separation, and an oxidative amidation reaction to form a continuous system, a multistep synthetic protocol has been demonstrated to produce amides under mild conditions using alcohols and amines as the starting materials. The use of inexpensive oxygen and urea hydrogen peroxide as the only oxidants affords an economical and adaptable synthetic route for amides.

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