Poly(tris(hydroxymethyl)acrylamidomethane)-based copolymers: a new class of acid-labile thermosensitive polymers

Literature Information

Publication Date 2012-05-30
DOI 10.1039/C2PY20309J
Impact Factor 5.582
Authors

Sophie Monge, Sarah Antoniacomi, Vincent Lapinte, Vincent Darcos, Jean-Jacques Robin


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Abstract

The present contribution reports on an original new class of acid-labile thermosensitive polyacrylamides, namely poly(tris(hydroxymethyl)acrylamidomethane-co-(5-acrylamido-5-hydroxymethyl-2,2-dimethyl-1,3-dioxane)) (P(THAM-co-pTHAM)), in which pTHAM only differed from THAM by an acetal group. The lower critical solution temperature (LCST) was controlled by varying the comonomer composition. Additionally, the properties of these new statistical copolymers were investigated and proved that such chemical structures were interesting for smart applications, notably for drug delivery due to the biocompatibility of low molecular weight PTHAM already demonstrated.

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Polymer Chemistry

Polymer Chemistry
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Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

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