![3-[7-Amino-3-(3-pyridinyl)pyrazolo[1,5-a]pyrimidin-6-yl]phenol structure](https://static.chemtradehub.com/structs/861/861249-77-6-025b.webp "3-[7-Amino-3-(3-pyridinyl)pyrazolo[1,5-a]pyrimidin-6-yl]phenol structure")
3-[7-Amino-3-(3-pyridinyl)pyrazolo[1,5-a]pyrimidin-6-yl]phenol
CAS Number:
861249-77-6
Molecular Formula:
C17H13N5O
Covalently incorporated protein–nanogels using AGET ATRP in an inverse miniemulsion
Literature Information
Publication Date
2011-03-24
DOI
10.1039/C1PY00050K
Impact Factor
5.582
Authors
Saadyah E. Averick, Andrew J. D. Magenau, Antonina Simakova, Bradley F. Woodman, Andrew Seong, Ryan A. Mehl, Krzysztof Matyjaszewski
View Original
Abstract
Using a genetically engineered protein, containing a non-natural amino acid bearing an atom transfer radical polymerization (ATRP) initiator, protein–nanogel hybrids (PNHs) were synthesized by activator generated by electron transfer (AGET) ATRP in an inverse miniemulsion. The route presented is an appropriate synthetic strategy to covalently and site specifically incorporate green fluorescent protein (GFP) into well-defined nanogels. These PNHs were analyzed using dynamic light scattering (DLS), UV-visible fluorescence spectroscopy and confocal microscopy to confirm the successful integration of GFP proteins into each nanogel (NG), while preserving its native tertiary structure.
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Source Journal
Polymer Chemistry
CiteScore:
8.6
Self-citation Rate:
7.3%
Articles per Year:
457
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
Recommended Compounds
2-Methyl-2-propanyl (1-cyclobutyl-3-hydroxy-2-propanyl)carbamate
CAS Number:
816429-99-9
Molecular Formula:
C12H23NO3
(3-Amino-piperidin-1-yl)-thiophen-3-yl-methanone hydrochloride
CAS Number:
1185316-70-4
Molecular Formula:
C10H15ClN2OS
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