Reverse orthogonal strategy for oligosaccharide synthesis‡§
Literature Information
Kohki Fujikawa, N. Vijaya Ganesh, Yih Horng Tan, Keith J. Stine, Alexei V. Demchenko
Herein, we report the invention of a novel expeditious concept for oligosaccharide synthesis. Unlike the classic orthogonal strategy based on leaving groups, the reverse approach is based on orthogonal protecting groups, herein p-methoxybenzyl and 4-pentenoyl, which allows for efficient oligosaccharide assembly in the reverse direction.
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