Syntheses, structural characterization and CO releasing properties of boranocarbonate [H3BCO2H]− derivatives

Literature Information

Publication Date 2010-08-24
DOI 10.1039/C0OB00099J
Impact Factor 3.876
Authors

Tamil Selvi Pitchumony, Bernhard Spingler, Roberto Motterlini, Roger Alberto


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Abstract

CO plays an important role in biological processes and molecules which release CO in a controllable way could therefore be used for medicinal purposes. Beside organometallic carbonyl complexes, boranocarbonate [H3BCO2H]− is one of the most promising candidates but releases CO too rapidly. In order to delay the CO release, we have prepared boranocarbamates [H3BCONH-R]− from [H3BCO2H]− which comprise histamine, morpholine, aniline and ethylene-diamine bound via amides to the {H3BCO} moiety. The syntheses of the new derivatives is described together with their structural characterization. These compounds release CO at a much slower rate than the parent compound and are therefore potential CO releasing molecules for biological and medicinal application.

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Organic & Biomolecular Chemistry
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