Ribosomal synthesis of dehydrobutyrine- and methyllanthionine-containing peptides

Literature Information

Publication Date 2009-04-30
DOI 10.1039/B904314D
Impact Factor 6.222
Authors

Kohei Torikai, Hiroshi Murakami


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Abstract

We report here the ribosomal synthesis of methyllanthionine-containing cyclic peptides involving a site-specific incorporation of vinylglycine under the reprogrammed genetic code, followed by the isomerization of the vinylglycine to dehydrobutyrine, and the subsequent intramolecular Michael addition of a cysteine residue placed at a downstream position of the vinylglycine.

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