Lactonizations of carboxylic acid-substituted 3-fluorodihydropyridines with electrophiles: peculiar behaviour of F+

Literature Information

Publication Date 2008-07-08
DOI 10.1039/B807092J
Impact Factor 6.222
Authors

Henri Rudler, Andrée Parlier, Louis Hamon, Patrick Herson, Jean-Claude Daran


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Abstract

Whereas for 3-fluorodihydropyridine-substituted carboxylic acids electrophiles such as HCl, iodine, bromine and peracids discriminate the double bond lacking and that bearing fluorine, no such differentiation took place in the case of electrophilic fluorine since the formation of both mono and gem-difluorolactones took place.

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