Fluorous synthesis of allylic fluorides: C–F bond formation as the detagging process‡
Literature Information
Sophie Boldon, Jane E. Moore, Véronique Gouverneur
A novel fluorous tagging–detagging strategy has been developed featuring a fluorination as the detagging process; fluorous allylsilanes were prepared by cross-metathesis and subsequently subjected to electrophilic fluorodesilylation; Selectfluor was used as the detagging reagent; the resulting allylic fluorides were successfully purified by fluorous solid phase extraction.
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