Synthesis and cytotoxicity of a cobaltcarbonyl–alkyne enkephalin bioconjugate

Literature Information

Publication Date 2007-10-22
DOI 10.1039/B712886J
Impact Factor 6.222
Authors

Merja A. Neukamm, Antonio Pinto, Nils Metzler-Nolte


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Abstract

A solid-phase synthesized propargyl derivative of the neuropeptide leucine-enkephalin (Enk) reacts rapidly and quantitatively with Co2(CO)8 to give the Co2(CO)6–alkyne labeled peptide 2, which is the first organometallic peptide bioconjugate to show significant toxicity against two different tumor cell lines.

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