Synthesis and cytotoxicity of a cobaltcarbonyl–alkyne enkephalin bioconjugate

Literature Information

Publication Date 2007-10-22
DOI 10.1039/B712886J
Impact Factor 6.222
Authors

Merja A. Neukamm, Antonio Pinto, Nils Metzler-Nolte


View Original

Abstract

A solid-phase synthesized propargyl derivative of the neuropeptide leucine-enkephalin (Enk) reacts rapidly and quantitatively with Co2(CO)8 to give the Co2(CO)6–alkyne labeled peptide 2, which is the first organometallic peptide bioconjugate to show significant toxicity against two different tumor cell lines.

Related Literature

Layer resolved evolution of the optical properties of α-sexithiophene thin films

Lidong Sun, Stephen Berkebile, Günther Weidlinger, Mariella Denk, Richard Denk, Michael Hohage, Georg Koller, Falko P. Netzer, Michael G. Ramsey, Peter Zeppenfeld

2012-08-20 Paper

DOI: 10.1039/C2CP42270K

Many M©Bn boron wheels are local, but not global minima

Yunlong Liao, Clara Leticia Cruz, Paul von Ragué Schleyer, Zhongfang Chen

2012-08-20 Paper

DOI: 10.1039/C2CP41521F

Photochemical and thermal spiropyran (SP)-merocyanine (MC) interconversion: a dichotomy in dependence on viscosity

Jamie Whelan, Dalia Abdallah, Konrad Piskorz, James T. C. Wojtyk, Julian M. Dust, Jean-Michel Nunzi, Shmaryahu Hoz, Erwin Buncel

2012-08-22 Paper

DOI: 10.1039/C2CP42259J

Neutral noble gas compounds exhibiting a Xe–Xe bond: structure, stability and bonding situation

Israel Fernández, Gernot Frenking

2012-05-10 Paper

DOI: 10.1039/C2CP41244F

Fabrication of n-type ZnO nanowire/graphene/p-type silicon hybrid structures and electrical properties of heterojunctions

Zhiwen Liang, Xiang Cai, Shaozao Tan, Peihua Yang, Long Zhang, Xiang Yu, Keqiu Chen, Hanming Zhu, Pengyi Liu

2012-10-16 Paper

DOI: 10.1039/C2CP43453A

Effect of heavy water on phospholipid membranes: experimental confirmation of molecular dynamics simulations

Lenka Beranová, Jana Humpolíčková, Jan Sýkora, Aleš Benda, Lukasz Cwiklik, Piotr Jurkiewicz, Gerhard Gröbner, Martin Hof

2012-07-19 Paper

DOI: 10.1039/C2CP41275F

Does the real ReN2 have the MoS2 structure?

Yachun Wang, Tiankai Yao, Jin-Lei Yao, Jingwu Zhang, Huiyang Gou

2012-10-23 Paper

DOI: 10.1039/C2CP43010J

Protonreduction to hydrogen in biological and chemical systems

2012-09-10 Perspective

DOI: 10.1039/C2CP42413D

CBe5E− (E = Al, Ga, In, Tl): planar pentacoordinate carbon in heptaatomic clusters

Abril C. Castro, Thomas Johnson, Jesus M. Ugalde, Yan-bo Wu, José M. Mercero, Thomas Heine, Kelling J. Donald

2012-04-25 Paper

DOI: 10.1039/C2CP40839B

You might also like

Compound Q&A

What precautions should be taken when handling 4-Methyl-6-(trifluoromethyl)quinoline (CAS: 40716-16-3)?

When handling 4-Methyl-6-(trifluoromethyl)quinoline (CAS: 40716-16-3), safety go...

40716-16-34-Methyl-6-(trifluor...
Compound Q&A

What is 4-(3,5-Difluorophenyl)aniline (CAS: 405058-00-6)?

4-(3,5-Difluorophenyl)aniline is an aromatic organic compound with the CAS numbe...

405058-00-64-(3,5-Difluoropheny...
Compound Q&A

How is 5-{[4-(Trifluoromethyl)phenyl]sulfanyl}-1,2,3-thiadiazole-4-carboxylic acid (CAS: 338982-07-3) typically synthesized?

5-{[4-(Trifluoromethyl)phenyl]sulfanyl}-1,2,3-thiadiazole-4-carboxylic acid can ...

338982-07-35-{[4-(Trifluorometh...
Compound Q&A

What is the market or research trend for 4-Benzylaniline hydrochloride (CAS: 6317-57-3)?

The market for 4-Benzylaniline hydrochloride (CAS: 6317-57-3) is steadily growin...

6317-57-34-Benzylaniline hydr...
Compound Q&A

Is [3-(Diethylsulfamoyl)phenyl]boronic acid (CAS: 871329-58-7) safe?

[3-(Diethylsulfamoyl)phenyl]boronic acid is generally considered safe when handl...

871329-58-7[3-(Diethylsulfamoyl...
Compound Q&A

What are the main uses of 3-Bromo-2,5-dimethoxyaniline (CAS: 115929-62-9)?

3-Bromo-2,5-dimethoxyaniline is mainly used in the pharmaceutical and chemical i...

115929-62-93-Bromo-2,5-dimethox...
Compound Q&A

What regulatory guidelines apply to N-Methyl-1-(5-methyl-1H-indol-3-yl)methanamine (CAS: 915922-67-7)?

N-Methyl-1-(5-methyl-1H-indol-3-yl)methanamine (CAS: 915922-67-7) is subject to ...

915922-67-7N-Methyl-1-(5-methyl...
Compound Q&A

What industries use Carbamic acid, N-[(5S)-5,6-diamino-6-oxohexyl]-, 1,1-dimethylethyl ester (CAS: 24828-96-4)?

This compound is primarily used in the pharmaceutical industry for the synthesis...

24828-96-4Carbamic acid, N-[(5...
Compound Q&A

How should 2-Methyl-2-propanyl [(1S,3R)-3-aminocyclohexyl]carbamate (CAS: 1298101-47-9) be stored?

2-Methyl-2-propanyl [(1S,3R)-3-aminocyclohexyl]carbamate (CAS: 1298101-47-9) sho...

1298101-47-92-Methyl-2-propanyl ...
Compound Q&A

What industries use Ethyl 2-bromo-4,4,4-trifluorobutanoate (CAS: 367-33-9)?

Ethyl 2-bromo-4,4,4-trifluorobutanoate (CAS: 367-33-9) is utilized in the pharma...

367-33-9Ethyl 2-bromo-4,4,4-...

Source Journal

Chemical Communications

Chemical Communications
CiteScore: 8.6
Self-citation Rate: 4.7%
Articles per Year: 2458

ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.