Highly efficient asymmetric reduction of arylpropionic aldehydes by Horse Liver Alcohol Dehydrogenase through dynamic kinetic resolution‡

Literature Information

Publication Date 2007-09-10
DOI 10.1039/B712290J
Impact Factor 6.222
Authors

Daria Giacomini, Paola Galletti, Arianna Quintavalla, Gabriele Gucciardo, Francesca Paradisi


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Abstract

The enantioselective synthesis of (2S)-2-phenylpropanol and (2S)-2-(4-iso-butylphenyl)propanol ((S)-Ibuprofenol) has been achieved by means of Horse Liver Alcohol Dehydrogenase (HLADH) in buffered aqueous solution or buffered organic solvent mixtures; under the reaction conditions, a dynamic kinetic resolution (DKR) process was realized with good reaction yields and enantiomeric ratios.

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