A concise stereocontrolled formal total synthesis of (±)-podophyllotoxin using sulfoxide chemistry
Literature Information
Publication Date
2003-12-05
DOI
10.1039/B312245J
Impact Factor
6.222
Authors
Mike Casey, Claire M. Keaveney
View Original
Abstract
A short stereoselective formal total synthesis of (±)-podophyllotoxin has been carried out from a sulfoxide, using a one-pot tandem conjugate addition/aldol/electrophilic aromatic substitution reaction to form a tetralin, which was converted into picropodophyllin in two steps.
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Source Journal
Chemical Communications
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