Direct asymmetric catalytic 1,2-addition of RZnX to aldehydes promoted by AlMe3 and reversal of expected stereochemistry

Literature Information

Publication Date 2007-08-15
DOI 10.1039/B710681E
Impact Factor 6.222
Authors

Jonathan Shannon, David Bernier, Daniel Rawson, Simon Woodward


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Abstract

Addition of AlMe3 to commercial THF solutions of RZnX (R = aryl, functionalised aryl, vinyl; X = Br, I) simultaneously promotes Schlenk equilibria (leading to competent nucleophiles) and the formation of an Al–Zn-ligand catalyst delivering 80–90% ee for Ar1CH(OH)Ar2 formation from aldehydes.

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