Direct asymmetric catalytic 1,2-addition of RZnX to aldehydes promoted by AlMe3 and reversal of expected stereochemistry
Literature Information
Jonathan Shannon, David Bernier, Daniel Rawson, Simon Woodward
Addition of AlMe3 to commercial THF solutions of RZnX (R = aryl, functionalised aryl, vinyl; X = Br, I) simultaneously promotes Schlenk equilibria (leading to competent nucleophiles) and the formation of an Al–Zn-ligand catalyst delivering 80–90% ee for Ar1CH(OH)Ar2 formation from aldehydes.
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