First total synthesis of murisolin
Literature Information
Naoyoshi Maezaki, Hiroaki Tominaga, Naoto Kojima, Minori Yanai, Daisuke Urabe, Tetsuaki Tanaka
The first and concise total synthesis of murisolin (1) was accomplished using asymmetric alkynylation and Sonogashira coupling as the key steps. The threo/trans/threo-type THF ring moiety was constructed with excellent stereoselectivity by asymmetric alkynylation of 1,6-heptadiyne to α-tetrahydrofuranic aldehyde, which was also prepared via the asymmetric alkynylation.
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