Precursor-directed biosynthesis of nonribosomal lipopeptides with modified glutamate residues

Literature Information

Publication Date 2007-05-29
DOI 10.1039/B706224A
Impact Factor 6.222
Authors

Amanda Powell, Majid Al Nakeeb, Barrie Wilkinson, Jason Micklefield


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Abstract

Precursor-directed biosynthesis of calcium dependent antibiotics (CDAs) with modified 3-trifluoromethyl and 3-ethyl glutamate residues was achieved by feeding synthetic glutamate analogues to a mutant strain of Streptomyces coelicolor impaired in the biosynthesis of the natural precursor (2S,3R)-3-methyl glutamic acid.

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