Evolution of chiral Lewis basic N-formamide as highly effective organocatalyst for asymmetric reduction of both ketones and ketimines with an unprecedented substrate scope

Literature Information

Publication Date 2007-05-09
DOI 10.1039/B703307A
Impact Factor 6.222
Authors

Siyu Wei, Jian Sun


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Abstract

L-Pipecolinic acid derived Lewis basic N-formamide 5e has been developed as a first highly effective catalyst for the asymmetric reduction of aromatic and aliphatic ketones as well as aromatic and aliphatic ketimines in good to high enantioselectivity.

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Chemical Communications

Chemical Communications
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