Palladium-catalyzed conjugate reduction of enones into α,β-dideuterioketones with hexamethyldisilane and deuterium oxide
Literature Information
Hidehito Otsuka, Eiji Shirakawa, Tamio Hayashi
Conjugated enones are reduced by readily available Me3SiSiMe3 and D2O in the presence of a catalytic amount of [PdCl(η3-C3H5)]2–PPh3 to give α,β-dideuterioketones.
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