Thrombin allostery‡
Literature Information
Enrico Di Cera, Michael J. Page, Alaji Bah, Leslie A. Bush-Pelc, Laura C. Garvey
Thrombin is a Na+-activated, allosteric serine protease that plays multiple functional roles in blood pathophysiology. Binding of Na+ is the major driving force behind the procoagulant, prothrombotic and signaling functions of the enzyme. This review summarizes our current understanding of the molecular basis of thrombin allostery with special emphasis on the kinetic aspects of Na+ activation. The molecular mechanism of thrombin allostery is a remarkable example of long-range communication that offers a paradigm for many other biological systems.
Recommended Journals

Journal of Natural Medicines

Russian Journal of Applied Chemistry

Journal of Peptide Science

Russian Chemical Bulletin

Saudi Pharmaceutical Journal

Russian Journal of General Chemistry

Journal of Saudi Chemical Society

Russian Journal of Organic Chemistry

Chemical Communications

Organic Process Research & Development
Related Literature
Aqueous copper-mediated reversible deactivation radical polymerization (RDRP) utilizing polyetheramine derived initiators‡
Jirui Zhang, Evelina Liarou, James Town, Yongguang Li, Alan M. Wemyss, David M. Haddleton
DOI: 10.1039/D0PY00555J
A highly hydrophilic cation exchange nonwoven with a further modifiable epoxy group prepared by radiation-induced graft polymerization
Xiao-han Pan, Jian-hua Zu
DOI: 10.1039/D1PY00866H
Hydrogen-bonding mediated self-assembly of amphiphilic ABA triblock copolymers into well-defined giant vesicles
Huiying Wang, Qiang Chen, Zhen Geng, Jingyi Rao, Bijin Xiong, Frédéric Lortie, Julien Bernard, Wolfgang H. Binder, Senbin Chen, Jintao Zhu
DOI: 10.1039/D1PY01061A
One-pot synthesis of amphiphilic multiblock poly(2-oxazoline)s via para-fluoro-thiol click reactions
Tieshuai Zhao, Ben Drain, Gokhan Yilmaz, C. Remzi Becer
DOI: 10.1039/D1PY00944C
Inspired by mussel adhesive protein: hydrophilic cationic copoly(2-oxazoline)s carrying catecholic side chains
Nils Lüdecke, Helmut Schlaad
DOI: 10.1039/D1PY00679G
Dicarboxylic acid-epoxy vitrimers: influence of the off-stoichiometric acid content on cure reactions and thermo-mechanical properties
Jonny J. Blaker, Constantinos Soutis, François Tournilhac, Matthieu Gresil
DOI: 10.1039/D0PY00342E
PNIPAM-immobilized gold-nanoparticles with colorimetric temperature-sensing and reusable temperature-switchable catalysis properties
Si Wu, Lei Lei, Yuzheng Xia, Susan Oliver, Xiaonong Chen, Cyrille Boyer, Zhiyong Nie, Shuxian Shi
DOI: 10.1039/D1PY01180D
You might also like
What is the market or research trend for N-(4-Methoxybenzyl)-2-pyridinamine (CAS: 52818-63-0)?
N-(4-Methoxybenzyl)-2-pyridinamine (CAS: 52818-63-0) is increasingly being used ...
What precautions should be taken when handling Ethyl 4-(2-chlorophenyl)-1,3-thiazole-2-carboxylate (CAS: 1050507-06-6)?
When handling Ethyl 4-(2-chlorophenyl)-1,3-thiazole-2-carboxylate, appropriate p...
What regulatory guidelines apply to diethyldiselane (CAS: 628-39-7)?
Diethyldiselane (CAS: 628-39-7) is classified under the Globally Harmonized Syst...
What is the market or research trend for oxocopper (CAS: 12053-18-8)?
The market for oxocopper (CAS: 12053-18-8) is primarily driven by its use in cat...
What is the market or research trend for 5-{[(2-Methyl-2-propanyl)oxy]carbonyl}-5-azaspiro[2.4]heptane-7-carboxylic acid?
The market for 5-{[(2-Methyl-2-propanyl)oxy]carbonyl}-5-azaspiro[2.4]heptane-7-c...
What is 2-(1-Pyrrolidinyl)-4-pyridinamine (CAS: 35981-63-6)?
2-(1-Pyrrolidinyl)-4-pyridinamine is a chemical compound with the CAS number 359...
What are the physical and chemical properties of 2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane (CAS: 91556-75-1)?
2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane (CAS: 91556-75-1) is a crystalline sol...
How is (S)-Alpha-allyl-proline hydrochloride (CAS: 129704-91-2) typically synthesized?
(S)-Alpha-allyl-proline hydrochloride is usually synthesized via a Wittig reacti...
What is 3-Methyl-1,2-oxazole-5-carboxylic acid (CAS: 4857-42-5)?
3-Methyl-1,2-oxazole-5-carboxylic acid (CAS: 4857-42-5) is an organic compound w...
How is Lys-SMCC-DM1 (CAS: 1281816-04-3) typically synthesized?
Lys-SMCC-DM1 is synthesized via a multi-step process involving the coupling of S...
Source Journal
Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.
![N-{15-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl}-2-(2-propyn-1-yloxy)acetamide structure N-{15-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl}-2-(2-propyn-1-yloxy)acetamide structure](https://static.chemtradehub.com/structs/210/2101206-92-0-2eb5.webp)



