![4,4-Difluoro-2-methyl-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline structure](https://static.chemtradehub.com/structs/119/1194032-23-9-f426.webp "4,4-Difluoro-2-methyl-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline structure")
4,4-Difluoro-2-methyl-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline
CAS Number:
1194032-23-9
Molecular Formula:
C11H17F2NO4
Highly unusual conversion of 1-alkyl-2-(bromomethyl)aziridines into 1-alkyl-2-(N-alkyl-N-ethylaminomethyl)aziridines using methyllithium
Literature Information
Publication Date
2007-01-15
DOI
10.1039/B616606G
Impact Factor
6.222
Authors
Matthias D'hooghe, Norbert De Kimpe
View Original
Abstract
1-Alkyl-2-(bromomethyl)aziridines were transformed into 1-alkyl-2-(N-alkyl-N-ethylaminomethyl)aziridines upon treatment with 2–3 equiv. of methyllithium in THF or Et2O; the peculiarity in this transformation comprises the presence of an N-ethyl group in the end-products as well as the total number of carbon atoms, resulting from a highly unusual reaction course with a novel SN2′-type substitution at the aziridine moiety and liberation of acetylene from an intermediate vinylamine as the key reaction steps.
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Source Journal
Chemical Communications
CiteScore:
8.6
Self-citation Rate:
4.7%
Articles per Year:
2458
ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry
Recommended Compounds
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Ethanone, 1-[4-chloro-2-(methylthio)-5-pyrimidinyl]-
CAS Number:
66116-82-3
Molecular Formula:
C7H7ClN2OS
![(3E)-3-[4-Hydroxy-3,5-bis(2-methyl-2-propanyl)benzylidene]dihydro-2(3H)-furanone structure](https://static.chemtradehub.com/structs/102/102271-49-8-cba7.webp "(3E)-3-[4-Hydroxy-3,5-bis(2-methyl-2-propanyl)benzylidene]dihydro-2(3H)-furanone structure")
(3E)-3-[4-Hydroxy-3,5-bis(2-methyl-2-propanyl)benzylidene]dihydro-2(3H)-furanone
CAS Number:
102271-49-8
Molecular Formula:
C19H26O3
![5,7-Dihydroxy-3-(4-hydroxyphenyl)-6-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]chromen-4-one structure](https://static.chemtradehub.com/structs/191/1914963-20-4-2b05.webp "5,7-Dihydroxy-3-(4-hydroxyphenyl)-6-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]chromen-4-one structure")
5,7-Dihydroxy-3-(4-hydroxyphenyl)-6-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]chromen-4-one
CAS Number:
1914963-20-4
Molecular Formula:
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