An integrated resource-efficient microfluidic device for parallelised studies of immobilised chiral catalysts in continuous flow via miniaturized LC/MS-analysis
Literature Information
Hannes Westphal, Rico Warias, Chris Weise, Daniele Ragno, Holger Becker, Matthias Spanka, Alessandro Massi, Roger Gläser, Christoph Schneider, Detlev Belder
A highly integrated microfluidic device is presented for the parallelised study of stereoselective heterogeneous catalytic processes. For the first time, multiple packed-bed μ-flow reactors are combined with a chiral separation unit on a chip that is seamlessly connected to mass spectrometry. By developing an automated fluidic setup, this device allows the performance of different catalysts to be studied in a single run, using only small amounts of resources. In this way, fully automated quasi-simultaneous testing of 2-packed bed reactors for enantioselectivity and conversion is possible, with a significant reduction in solvent and substrate consumption compared to classical tube reactor HPLC-MS testing.
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Source Journal
Reaction Chemistry & Engineering

Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.














