Stereochemistry of rHint1 hydrolase assisted cleavage of P–N bond in nucleoside 5′-O-phosphoramidothioates

Literature Information

Publication Date 2007-02-22
DOI 10.1039/B615160D
Impact Factor 6.222
Authors

Agnieszka Krakowiak, Renata Kaczmarek, Janina Baraniak, Michał Wieczorek, Wojciech J. Stec


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Abstract

The Hint-1 hydrolase assisted cleavage of the P–N bond in adenosine-5′-O-[N-(tryptophanylamide)]phosphoramidothioate proceeds with retention of configuration at the phosphorus atom which is consistent with the formation of a covalent enzyme–substrate complex.

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