Promoting helicity in carbohydrate-containing foldamers through long-range hydrogen bonds

Literature Information

Publication Date 2006-11-27
DOI 10.1039/B614294J
Impact Factor 6.222
Authors

David Rodríguez-Lucena, Juan M. Benito, Carmen Ortiz Mellet, José M. García Fernández


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Abstract

A sensor system to probe the propensity of carbohydrates to induce helical structures through long-range hydrogen bonds, based on a C2-symmetric xylylene bis(thiourea) arrangement, is reported; the formation of intermolecular complexes with benzoate anion promotes helix uncoiling, the free energy of the process being related to helix stability.

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