Spirocyclic helical compounds as binding agents for bulged RNA, including HIV-2 TAR

Literature Information

Publication Date 2006-09-14
DOI 10.1039/B610007D
Impact Factor 6.222
Authors

Ziwei Xiao, Na Zhang, Yiqing Lin, Graham B. Jones, Irving H. Goldberg


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Abstract

Based on fluorescence binding studies and 1D 1H NMR studies, designed synthetic analogues of NCSi-gb bind specifically with two-base bulged RNA, including HIV-2 TAR RNA, making them potential lead compounds for antiviral drug development.

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