Spirocyclic helical compounds as binding agents for bulged RNA, including HIV-2 TAR
Literature Information
Ziwei Xiao, Na Zhang, Yiqing Lin, Graham B. Jones, Irving H. Goldberg
Based on fluorescence binding studies and 1D 1H NMR studies, designed synthetic analogues of NCSi-gb bind specifically with two-base bulged RNA, including HIV-2 TAR RNA, making them potential lead compounds for antiviral drug development.
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