Organolithium-mediated conversion of β-functionalised aziridines into alkynyl amino alcohols and diamines

Literature Information

Publication Date 2005-10-20
DOI 10.1039/B510920E
Impact Factor 6.222
Authors

Jianhui Huang, Peter O'Brien


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Abstract

The direct conversion of dihydrofuran and dihydropyrrole N-triisopropylbenzenesulfonyl aziridines into alkynyl amino alcohols and diamines respectively can be achieved using 3 equiv. sec-butyllithium–PMDETA in THF; use of n-butyllithium and (−)-sparteine in Et2O gave an alkynyl amino alcohol in 60% ee.

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Inside front cover

Cover

DOI: 10.1039/C8CC90058B

Contents list

Front/Back Matter

DOI: 10.1039/C5EW90024G

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