Recognition of guanines at a double helix–coil junction in DNA by a trinuclear copper complex

Literature Information

Publication Date 2005-08-31
DOI 10.1039/B509690A
Impact Factor 6.222
Authors

Sunita Thyagarajan, Kenneth D. Karlin, Steven E. Rokita


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Abstract

Coordination between guanine N7 and a trinuclear copper complex appears critical for selective and efficient strand scission of DNA at a helix–coil junction as indicated by the lack of reactivity of comparable DNA containing 7-deazaguanine in place of guanine; both the base pair at the junction and coil flexibility also modulate the specificity of DNA oxidation.

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