On the CH⋯Cu agostic interaction: chiral copper(ii) compounds with ephedrine and pseudoephedrine derivatives

Literature Information

Publication Date 2005-06-24
DOI 10.1039/B505554G
Impact Factor 6.222
Authors

Miguel Castro, Julián Cruz, Horacio López-Sandoval, Norah Barba-Behrens


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Abstract

The ephedrine derivative, (H2ceph), yields [Cu(Hceph)2], showing a CH⋯Cu(II) agostic interaction; while in the analogous compound [Cu(Hcpse)2], with pseudoephedrine (H2cpse), that interaction is absent, despite the fact that these two diasteromers differ only in the orientation of the methyl and phenyl groups: erythro in H2ceph and threo in H2cpse. The X-ray crystal structure of [Cu(Hceph)2], indicates a Cu⋯HC length of 2.454 Å and the theoretical study reveals the formation of a Cu⋯HC bond since the associated electronic density shows both a bond critical point and a bond ring critical point.

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