Rapid cloning and expression of a fungal polyketide synthase gene involved in squalestatin biosynthesis
Literature Information
Russell J. Cox, Frank Glod, Deirdre Hurley, Colin M. Lazarus, Thomas. P. Nicholson, Brian A. M. Rudd, Thomas J. Simpson, Barrie Wilkinson, Ying Zhang
PCR primers designed to selectively amplify the unique C-methyltransferase domain of fungal polyketide synthases were used to selectively clone a polyketide synthase gene involved in the biosynthesis of the squalene synthase inhibitor squalestatin S1 1, heterologous expression of which led to the biosynthesis of the squalestatin side-chain.
Related Literature
Construction of biodegradable core cross-linked nanoparticles from near infrared dyes encoded in polyprodrug amphiphiles and investigation of their synergistic anticancer activity
Xiaoxu Mao, Shoukui Hu, Ke Shang, Guangwei Yang, Jinhao Yan, Chao Ma, Jun Yin
DOI: 10.1039/D1PY00128K
Polymers and boron neutron capture therapy (BNCT): a potent combination
Anaïs Pitto-Barry
DOI: 10.1039/D0PY01392G
Visible light-degradable supramolecular gels comprising cross-linked polyrotaxanes capped with trithiocarbonate groups
Tae Woong Kang, Atsushi Tamura, Yoshinori Arisaka, Nobuhiko Yui
DOI: 10.1039/D1PY00569C
The synthesis of thermoresponsive POSS-based eight-arm star poly(N-isopropylacrylamide): A comparison between Z-RAFT and R-RAFT strategies
Bo Pang, Rui Liu, Guang Han, Wei Wang
DOI: 10.1039/D1PY00087J
High molar mass poly(ricinoleic acid) via entropy-driven ring-opening metathesis polymerization
Marc A. Hillmyer
DOI: 10.1039/D1PY00185J
A dual stimuli responsive natural polymer based superabsorbent hydrogel engineered through a novel cross-linker
Safiya Nisar, Sonal Chauhan, Gurmeet Singh, Virender Singh, Sunita Rattan
DOI: 10.1039/D0PY01729A
Correction: Synthesis and structural characterization of bio-based bis(cyclic carbonate)s for the preparation of non-isocyanate polyurethanes
Kamila Błażek, Hynek Beneš, Zuzana Walterová, Sabina Abbrent, Arantxa Eceiza, Tamara Calvo-Correas, Janusz Datta
DOI: 10.1039/D1PY90040D
RAFT polymerisation of trifluoroethylene: the importance of understanding reverse additions
Marc Guerre, Cédric Totée, Gilles Silly, Olinda Gimello, Bruno Améduri, Jean-François Tahon, Rinaldo Poli, Sophie Barrau, Vincent Ladmiral
DOI: 10.1039/D0PY01754J
You might also like
What precautions should be taken when handling lithium chloride hydrate (1:1:1) (CAS: 16712-20-2)?
When handling lithium chloride hydrate (1:1:1) (CAS: 16712-20-2), it is importan...
Is 4-(4H-1,2,4-Triazol-4-yl)piperidine (CAS: 690261-92-8) safe?
4-(4H-1,2,4-Triazol-4-yl)piperidine is generally considered safe for use in phar...
How should waste containing 1,3-Thiazole-2-carboxamide (CAS: 16733-85-0) be handled?
Waste containing 1,3-Thiazole-2-carboxamide (CAS: 16733-85-0) should be collecte...
What regulatory guidelines apply to 5-(Difluoromethyl)-2-fluorobenzonitrile (CAS: 934175-58-3)?
5-(Difluoromethyl)-2-fluorobenzonitrile (CAS: 934175-58-3) is subject to regulat...
How is Methyl 3-acetamido-2-thiophenecarboxylate (CAS: 22288-79-5) typically synthesized?
Methyl 3-acetamido-2-thiophenecarboxylate can be synthesized by the reaction of ...
What is 4-Isoquinolinecarbonitrile (CAS: 34846-65-6)?
4-Isoquinolinecarbonitrile is a chemical compound with the CAS number 34846-65-6...
How should Methyl 1H-1,2,3-triazole-4-carboxylate (CAS: 877309-59-6) be stored?
Store Methyl 1H-1,2,3-triazole-4-carboxylate (CAS: 877309-59-6) in a cool, dry p...
What regulatory guidelines apply to 6-Bromo[1,3]thiazolo[5,4-b]pyridin-2-amine (CAS: 1160791-13-8)?
6-Bromo[1,3]thiazolo[5,4-b]pyridin-2-amine (CAS: 1160791-13-8) is subject to the...
Is (2S,3S)-2-Ammonio-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoate (CAS: 23651-95-8) safe?
(2S,3S)-2-Ammonio-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoate (CAS: 23651-95-8) ...
What are the physical and chemical properties of 7-bromo-3-methyl-3,4-dihydroquinazolin-4-one (CAS: 1293987-84-4)?
7-Bromo-3-methyl-3,4-dihydroquinazolin-4-one is a solid with a crystalline form....
Source Journal
Chemical Communications

ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry











![[(2R)-6,6-Dimethyl-2-morpholinyl]methanol hydrochloride (1:1) structure [(2R)-6,6-Dimethyl-2-morpholinyl]methanol hydrochloride (1:1) structure](https://static.chemtradehub.com/structs/141/1416444-88-6-e06a.webp)
![5,10-Dihydroindeno[2,1-a]indene structure 5,10-Dihydroindeno[2,1-a]indene structure](https://static.chemtradehub.com/structs/654/6543-29-9-71ca.webp)

