Site-specific oxidative cleavage of DNA by metallosalen–DNA conjugates

Literature Information

Publication Date 2004-09-24
DOI 10.1039/B410493E
Impact Factor 6.222
Authors

Jennifer L. Czlapinski, Terry L. Sheppard


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Abstract

Ni-salen–DNA conjugates, prepared by template-directed synthesis, targeted oxidative adduct formation and strand scission at deoxyguanosine sites in complementary DNA strands of Watson–Crick duplexes.

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