Sensitivity increase in molecular recognition by decrease of the sensing particle size and by increase of the receptor binding site – a case with chemomechanical polymers

Literature Information

Publication Date 2004-09-24
DOI 10.1039/B409331C
Impact Factor 6.222
Authors

Hans-Jörg Schneider, Liu Tianjun, Nino Lomadze


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Abstract

For the first time it is shown that diminishing the particle size of a chemomechanical polymer leads to a dramatic sensitivity increase, with a large response triggered e.g. by action of external AMP; as illustrated with carbohydrate model complexes in solution, the necessary high binding affinity can be achieved by providing an excess of recognition units in one of the partners.

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