Characterisation of the interactions of aromatic amino acids with diacetyl phosphatidylcholine

Literature Information

Publication Date 2004-01-21
DOI 10.1039/B312184D
Impact Factor 3.676
Authors

John M. Sanderson, Eleanor J. Whelan


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Abstract

A simple bimolecular system for characterising the interactions of amino acids with diacyl-3-phosphatidylcholines has been developed. The system contains two components: an N-acetyl amino acid N′-alkyl amide and diacetyl-3-sn-phosphatidylcholine (DAPC). Interactions between a series of aromatic amino acids and DAPC have been characterised by 1H NMR techniques. Of the amino acids examined, tryptophan and tyrosine were shown to have particularly favourable interactions with the DAPC choline headgroup. Our observations are consistent with the previously reported tendency for these amino acids to occur preferentially at the lipid-water interface. Using data from ROESY experiments and complexation-induced chemical shift changes, we have been able to generate molecular models for the tryptophan–DAPC adduct that are consistent with the observed results. The adduct is characterised by amide carbonyl–cation interactions, hydrogen bonding and cation–π interactions.

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Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
CiteScore: 5.5
Self-citation Rate: 10.3%
Articles per Year: 3036

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.

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