Metastability and supersaturation limit for lysozyme crystallization

Literature Information

Publication Date 2003-12-04
DOI 10.1039/B312151H
Impact Factor 3.676
Authors

Roberto Piazza


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Abstract

We investigate the ionic strength and temperature dependence of metastability with respect to crystallization in lysozyme solution. The supersaturation limit c* shows a simple scaling relation with salt concentration and, together with the equilibrium solubility csat, approximately factorizes into two terms, respectively accounting for electrostatic and temperature effects. The supersaturation ratio S = c*/csat monotonically increases with the addition of salt. While the dependence of solution properties on the ionic strength is consistent with a recent model by Sear and Warren, temperature effects highlight the importance of hydrophobic contributions.

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Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
CiteScore: 5.5
Self-citation Rate: 10.3%
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Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.

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