Cell-permeable small molecule probes for site-specific labeling of proteins

Literature Information

Publication Date 2003-10-29
DOI 10.1039/B309196A
Impact Factor 6.222
Authors

Dawn S. Y. Yeo, Rajavel Srinivasan, Mahesh Uttamchandani, Qing Zhu


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Abstract

We have successfully synthesized a number of small molecule probes designed for site-specific labeling of N-terminal cysteine-containing proteins expressed in live cells. Their utility for site-specific, covalent modifications of proteins was successfully demonstrated with purified proteins in vitro, and with live bacterial cells in vivo.

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Chemical Communications

Chemical Communications
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