A solid-state NMR study of the structure and molecular mobility of α-keratin
Literature Information
Melinda J. Duer, Nicky McDougal, Rachel C. Murray
A solid-state NMR study of an α-keratin sourced from equine hoof has revealed a strong dependence of molecular conformation and molecular dynamics on the degree of hydration of the material. 13C cross-polarization, magic-angle spinning experiments were used in conjunction with two-dimensional 13C-1H WISE and 2H NMR to provide a detailed examination of these factors. In particular, dehydration results in a much more rigid and ordered structure, with a loss of α-helical components in the structure and breaking of cysteine disulfide linkages. These results have clear implications for our understanding of the material properties of equine hoof wall.
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Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.



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