Spin trapping of superoxide in the presence of β-cyclodextrins
Literature Information
Hakim Karoui, Antal Rockenbauer, Sylvie Pietri, Paul Tordo
The trapping of superoxide anion with DMPO and DEPMPO has been carried out in the presence of a methylated β-cyclodextrin, Me-β-CD; inclusion of the spin adducts in the cavity of Me-β-CD resulted in a seven-fold increase of their half-life (t1/2 = 96 min for DEPMPO-superoxide spin adduct) and in their protection towards glutathione peroxidase (Gpx) and also ascorbate anion in the case of DEPMPO.
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![1-{3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl}-2,3-dihydroxy-1-propanone structure 1-{3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl}-2,3-dihydroxy-1-propanone structure](https://static.chemtradehub.com/structs/122/1226872-27-0-e037.webp)
