A reagentless electrochemical biosensor based on a protein scaffold
Literature Information
Sulay D. Jhaveri, J. Matthew Mauro, Harold M. Goldston, Caroline L. Schauer, Leonard M. Tender, Scott A. Trammell
Apo-myoglobin, labeled with the environmentally sensitive redox probe RuII(NH3)4(1,10-phenanthroline-5-maleimide)2+, was immobilized onto gold electrodes modified with 11-mercaptoundecanoic acid and subsequently labeled with biotin; avidin binding to the immobilized biotin was specifically and quantitatively detected by a change in cyclic voltammetry of the co-immobilized probe.
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Chemical Communications

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