Solvent-free synthesis and purification of poly[2-(dimethylamino)ethyl methacrylate] by atom transfer radical polymerization

Literature Information

Publication Date 2003-01-13
DOI 10.1039/B208703K
Impact Factor 6.222
Authors

Nadège Pantoustier, Sébastien Moins, Michaël Wautier, Philippe Degée, Philippe Dubois


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Abstract

Solvent-free synthesis of well-defined poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) (co)polymers was performed by atom transfer radical polymerization conducted under very mild conditions (in bulk at 25 °C). The pH-dependence and the thermo-responsive behaviour of PDMAEMA in aqueous solution were operated to isolate and purify the (co)polymers without using any organic solvent or further catalyst extraction. The viscosity in aqueous solution of so-purified PDMAEMA homopolymers and their block copolymers with poly(ethylene glycol) (PEG) was studied as a function of molar mass and concentration and a typical polyelectrolyte behaviour was observed. these catalyst-deprived polycations are able to form stable and non toxic complexes with DNA, showing good transfection efficacies in gene therapy.

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Chemical Communications

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ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry

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