A simple kinetic model to describe the progression of prion disease

Literature Information

Publication Date 2001-09-24
DOI 10.1039/B104480J
Impact Factor 3.676
Authors

V. Vitagliano, G. D'Errico


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Abstract

A simple mathematical model based on bistationary autocatalytic kinetics is proposed to describe a possible progression of prion disease. The model accounts for both the sporadic and the infectious manifestation of the disease. Peculiarly, it shows how the disease grows if the concentration of the infectious agent (the prion PrPSc) is added to the metabolic system over a threshold concentration, while for a lower concentration the disease cannot grow.

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Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
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